Year: 2011
Type: article
Abstract: Background Identification of cellular factors that negatively or positively regulate HIV-1 replication is essential to understand HIV-1 pathogenesis for development of novel antiviral treatments. The human cytidine deaminase APOBEC3G (A3G) is an intrinsic antiviral factor important for the host-mediated defence against HIV-1. We and others recently identified a panel of A3G-interacting RNA-binding proteins (RBPs) that focused our search for novel HIV-1 cofactors and restriction factors onto these proteins. Mov10, a superfamily-1 putative RNA helicase, interacts with A3G in an RNA-dependent manner. Mov10 associates with the RNA-induced silencing complex pathway and localises to mRNA processing bodies (PBs). Furthermore, orthologs of Mov10 in Arabidopsis thaliana and Drosophila melanogaster are necessary for antiviral small RNA-mediated silencing. Thus, we investigated whether Mov10 restricts HIV-1 replication.
Source: Retrovirology
Institution: King's College London
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,890
OpenAlex ID: W2037656573