Year: 2010
Type: article
Abstract: Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.
Source: Virulence
Authors: Alistair J.P. Brown, Michelle D. Leach, Susan Nicholls
Institution: University of Aberdeen
Language: English
Topic: Heat shock proteins research
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,557
Awards: G1147502531, G1669550096, Combinatorial responses of fungal pathogens to their human hosts: an Integrative Systems Biology approach, Candida albicans cell surface: regulation of the host-fungus interaction., Central role of Nrg1 in the niche-specific coordination of morphogenesis stress responses and metabolism in the fungal pathogen Candida albicans, Role of the Heat Shock Transcription Factor in the Fungal Pathogen Candida albicans
OpenAlex ID: W2037695964