Work

Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages

Year: 2014

Type: article

Abstract: In gastrointestinal stromal tumor (GIST), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.

Source: OncoImmunology

DOI: 10.4161/onci.28463

Authors: Michael J Cavnar, Ronald P DeMatteo

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913