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Pathophysiological Roles of PPARγ in Gastrointestinal Epithelial Cells

Year: 2008

Type: article

Abstract: Although the highest levels of PPARgamma expression in the body have been reported in the gastrointestinal epithelium, little is known about the physiological functions of that receptor in the gut. Moreover, there is considerable controversy concerning the effects of thiazolidinedione PPARgamma agonists on the two major diseases of the gastrointestinal track: colorectal cancer and inflammatory bowel disease. We will undertake to review both historical and recently published data with a view toward summarizing what is presently known about the roles of PPARgamma in both physiological and pathological processes in the gastrointestinal epithelium.

Source: PPAR Research

DOI: 10.1155/2008/148687

Authors: Brian M. Necela, E. Aubrey Thompson

Institutions: Mayo Clinic in Florida, Mayo Clinic Comprehensive Cancer Center (Florida)

Language: English

Topic: Peroxisome Proliferator-Activated Receptors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,630