Work

Resin Capsules: Permeable Containers for Parallel/Combinatorial Solid-Phase Organic Synthesis

Year: 2008

Type: article

Abstract: A resin capsule is a permeable container for resin beads designed for multiple/combinatorial solid-phase organic synthesis. Resin capsules consist of a high density polyethylene ring sealed with peek mesh on both sides. The cylindrical shape of resin capsules enabled space-saving packing into plastic columnlike reaction vessels commonly used for solid-phase organic synthesis. Resin capsules have been evaluated for their use in combinatorial synthesis, and a set of model compounds with excellent purity was prepared.

Source: Journal of Combinatorial Chemistry

DOI: 10.1021/cc800072g

Authors: Isabelle Bouillon, Miroslav Soural, Viktor Krchňák

Institution: University of Notre Dame

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: G1242290637, Diversity oriented combinational synthesis of bisheterocyclic libraries