Work

Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis

Year: 2012

Type: article

Abstract: Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans, pathogen of dental caries, and ulcerative colitis (UC) has not been reported. We investigated the effect of various S. mutans strains on dextran sodium sulfate (DSS)-induced mouse colitis. Administration of TW295, the specific strain of S. mutans, caused aggravation of colitis; the standard strain, MT8148 did not. Localization of TW295 in hepatocytes in liver was observed. Increased expression of interferon-γ in liver was also noted, indicating that the liver is target organ for the specific strain of S. mutans-mediated aggravation of colitis. The detection frequency of the specific strains in UC patients was significantly higher than in healthy subjects. Administration of the specific strains of S. mutans isolated from patients caused aggravation of colitis. Infection with highly-virulent specific types of S. mutans might be a potential risk factor in the aggravation of UC.

Source: Scientific Reports

DOI: 10.1038/srep00332

Authors: Ayuchi Kojima, Kazuhiko Nakano, Koichiro Wada, Hirokazu Takahashi, Kazufumi Katayama, Masato Yoneda, Takuma Higurashi, Ryota Nomura, Kazuya Hokamura, Yoshinori Muranaka, Nobuyuki Matsuhashi, Kazuo Umemura, Yoshinori Kamisaki, Atsushi Nakajima, Takashi Ooshima

Institutions: The University of Osaka, Yokohama City University, Hamamatsu University, Hamamatsu University School of Medicine, NTT (Japan)

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690

Funders: Ministry of Education, Culture, Sports, Science and Technology, Tokyo Medical and Dental University, Osaka Medical Research Foundation for Intractable Diseases, Japan Society for the Promotion of Science

Awards: Investigation of mechanism of systemic diseases caused by oral bacteria and development of preventive procedures, Role of Mcl-1 expression on tumor cell growth and metastasis, Analysis of virulence factors in cariogenic bacteria for cardiovascular diseases, Pathogenic mechanism for aggravation of inflammatory bowel diseases caused by oral bacteria and specification of highly virulent strains, Challenging research for elucidating the role of oral bacteria in the pathogenesis of IBD, Analyses of pathogenicity of collagen-binding protein of S.mutans for cardiovascular diseases, Elucidation of mechanism for development of cerebrovascular diseases associated with oral bacteria and pursuit of preventive approach

OpenAlex ID: W2037973217

FWCI: 2.655

Cites: 31

Cited by: 129

Related to: 10