Work

Validation of Blood-Based Assays Using Dried Blood Spots for Use in Large Population Studies

Year: 2014

Type: article

Abstract: Assessment of health in large population studies has increasingly incorporated measures of blood-based biomarkers based on the use of dried blood spots (DBS). The validity of DBS assessments made by labs used by large studies is addressed by comparing assay values from DBS collected using conditions similar to those used in the field with values from whole blood samples. The DBS approach generates values that are strongly related to whole blood levels of HbA1c, cystatin C, and C-reactive protein. Assessing lipid levels reliably with DBS appears to be a greater challenge. However, even when DBS values and values from venous blood are highly correlated, they are often on a different scale, and using conventional cutoffs may be misleading.

Source: Biodemography and Social Biology

DOI: 10.1080/19485565.2014.901885

Authors: Eileen Crimmins, Jung Ki Kim, Heather McCreath, Jessica Faul, David Weir, Teresa Seeman

Institutions: University of Southern California, University of California, Los Angeles, University of Michigan, Institute for Social Research

Language: English

Topic: Clinical Laboratory Practices and Quality Control

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging