Work

Tipping the Balance in the Powerhouse of the Cell to “Protect” Colorectal Cancer

Year: 2012

Type: article

Abstract: Mitochondria are the bioenergetic cen-ters of eukaryotic cells that produce ATP through oxidative phosphorylation. A by-product of oxidative phosphorylation is the generation of reactive oxygen species (ROS). Cancer cells exhibit high basal levels of oxidative stress due to activation of oncogenes, loss of tumor suppressors, and the effects of the tumor microenvi-ronment [1]. A large body of evidence suggests important roles for oxygen free radicals in the mutagenesis that drives carcinogenesis [2], the expansion of tumor clones, and the acquisition of malignant properties [3].

Source: PLoS Genetics

DOI: 10.1371/journal.pgen.1002758

Authors: Dawit Kidane, Joann B. Sweasy

Institution: Yale University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,043