Work

Guanidinium‐Modified Phthalocyanines as High‐Affinity G‐Quadruplex Fluorescent Probes and Transcriptional Regulators

Year: 2009

Type: article

Abstract: Fluorescence is ON and transcriptional control is OFF when the guanidinium-modified zinc phthalocyanine Zn-DIGP binds a G-quadruplex DNA from the c-Myc promoter. With an equilibrium dissociation constant Kd of less than 2 nM, this interaction is the strongest binding interaction between a G-quadruplex structure and a small molecule reported to date.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200903685

Authors: Jawad Alzeer, Balayeshwanth R. Vummidi, Phillipe J. C. Roth, Nathan W. Luedtke

Institution: University of Zurich

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2038138229

FWCI: 6.971

Cites: 54

Cited by: 192

Related to: 10