Work

Plasmonic nanoprobes for SERS biosensing and bioimaging

Year: 2009

Type: review

Abstract: This article provides an overview of the development and application of plasmonic nanoprobes developed in our laboratory for biosensing and bioimaging. We describe the use of plasmonics surface-enhanced Raman scattering (SERS) gene probes for the detection of diseases using DNA hybridization to target biospecies (HIV gene, breast cancer genes etc.). For molecular imaging, we describe a hyperspectral surface-enhanced Raman imaging (HSERI) system that combines imaging capabilities with SERS detection to identify cellular components using Raman dye-labeled silver nanoparticles in cellular systems The detection of specific target DNA sequences associated with breast cancer using "molecular sentinel" nanoprobes and the use of a plasmonic nanosensor to monitor pH in single cells are presented and discussed.

Source: Journal of Biophotonics

DOI: 10.1002/jbio.200910015

Authors: Tuan Vo‐Dinh, Hsin‐Neng Wang, Jonathan Scaffidi

Institution: Duke University

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

Open Access status: bronze

Funders: National Institute of Environmental Health Sciences, National Institute of Biomedical Imaging and Bioengineering

Awards: Nonobiosensors for Probing Chemical Exposure and Metabolism Pathways of Individua, Ultra-High-Throughput Screening (uHTS) Based on Surface*