Work

In vivo optical-resolution photoacoustic computed tomography with compressed sensing

Year: 2012

Type: article

Abstract: Optical-resolution photoacoustic microscopy is becoming a powerful research tool for studying microcirculation in vivo. Moreover, ultrasonic-array-based optical-resolution photoacoustic computed tomography (OR-PACT), providing comparable resolution at an improved speed, has opened up new opportunities for studying microvascular dynamics. In this Letter, we have developed a compressed sensing with partially known support (CS-PKS) photoacoustic reconstruction strategy for OR-PACT. Compared with conventional backprojection reconstruction, the CS-PKS strategy was shown to produce high-quality in vivo OR-PACT images with threefold less measurement data, which can be leveraged to improve the data acquisition speed and costs of OR-PACT systems.

Source: Optics Letters

DOI: 10.1364/ol.37.004573

Authors: Jing Meng, Lihong V. Wang, Dong Liang, Liang Song

Institutions: Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, Washington University in St. Louis

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Development and Reform Commission of Shenzhen Municipality

Awards: 适用于肿瘤血管生成的亚微米分辨率活体光声成像研究, G5804537327