Work

Cloning and Chromosomal Localization of MouseAquaporin 4:Exclusion of a Candidate Mutant Phenotype,Ataxia

Year: 1997

Type: article

Abstract: Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype.

Source: Genomics

DOI: 10.1006/geno.1997.4641

Authors: L.Christine Turtzo, M.Douglas Lee, Mingqi Lu, Barbara L. Smith, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Peter Agre

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Frederick National Laboratory for Cancer Research

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,980

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: G1166265511, Medical Scientist Training Program, G2351381531, G8741346891

OpenAlex ID: W2038437924

FWCI: 1.421

Cites: 15

Cited by: 28

Related to: 10