Work

Synthesis of Cyclic α-Aminophosphonates through Copper-Catalyzed Enamine Activation

Year: 2013

Type: article

Abstract: A copper-catalyzed tandem cyclization triggered addition strategy that relies on electrophilic enamine activation has been used to synthesize various cyclic α-aminophosphonates derivatives in good to excellent yields. Both five and six membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper catalyzed enamine activation is proposed.

Source: Synthesis

DOI: 10.1055/s-0032-1317984

Authors: Bo Xu, Gerald Hammond, Junbin Han, Robert Paton

Institutions: University of Louisville, University of Oxford

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Transition metal catalyzed construction of ring systems