Work

Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin

Year: 2013

Type: article

Abstract: We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.

Source: Journal of Virology

DOI: 10.1128/jvi.02975-12

Authors: Cyrille Dreyfus, Damian C. Ekiert, Ian A. Wilson

Institution: Scripps Research Institute

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Energy, National Institute of Allergy and Infectious Diseases, National Center for Research Resources, Basic Energy Sciences