Work

In Vitro Potency and In Vivo Efficacy of a Novel Bis-Indole Antimicrobial Compound in Reducing Catheter Colonization

Year: 2012

Type: article

Abstract: Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.05521-11

Authors: Mohammad D. Mansouri, Timothy J. Opperman, John D. Williams, Charles Stager, Rabih O. Darouiche

Institutions: Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Microbiotix (United States)

Language: English

Topic: Antimicrobial agents and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases