An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults
Year: 2015
Type: article
Abstract: Myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) are hematologically diverse stem cell malignancies sharing phenotypic features of both myelodysplastic syndromes and myeloproliferative neoplasms. There are currently no standard treatment recommendations for most adult patients with MDS/MPN. To optimize efforts to improve the management and disease outcomes, it is essential to identify meaningful clinical and biologic end points and standardized response criteria for clinical trials. The dual dysplastic and proliferative features in these stem cell malignancies define their uniqueness and challenges. We propose response assessment guidelines to harmonize future clinical trials with the principal objective of establishing suitable treatment algorithms. An international panel comprising laboratory and clinical experts in MDS/MPN was established involving 3 independent academic MDS/MPN workshops (March 2013, December 2013, and June 2014). These recommendations are the result of this collaborative project sponsored by the MDS Foundation.
Source: Blood
Authors: Michael R. Savona, Luca Malcovati, Rami Komrokji, Ramon V. Tiu, Tariq I. Mughal, Attilio Orazi, Jean-Jacques Kiladjian, Eric Padron, Eric Solary, Raoul Tibes, Raphael Itzykson, Mario Cazzola, Ruben Mesa, Jaroslaw Maciejewski, Pierre Fenaux, Guillermo Garcia-Manero, Aaron Gerds, Guillermo Sanz, Charlotte M. Niemeyer, Francisco Cervantes, Ulrich Germing, Nicholas C. P. Cross, Alan F. List
Institutions: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, University of Pavia, Policlinico San Matteo Fondazione, University of South Florida, Moffitt Cancer Center, Cleveland Clinic, Tufts Medical Center, Weill Cornell Medicine, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Louis, Université Paris Diderot, Institut Gustave Roussy, Mayo Clinic, Mayo Clinic in Arizona, The University of Texas MD Anderson Cancer Center, Hospital Universitari i Politècnic La Fe, University of Freiburg, Universitat de Barcelona, Heinrich Heine University Düsseldorf, Wessex Regional Genetics Laboratory, University of Southampton
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2038795176