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Inositol 1,4,5‐trisphosphate may be a signal for f‐Met‐Leu‐Phe‐induced intracellular Ca mobilisation in human leucocytes (HL‐60 cells)

Year: 1984

Type: article

Abstract: Permeabilised, dimethyl sulphoxide-differentiated HL-60 human myelomonocytic leukemia cells accumulate 45Ca in an ATP-dependent manner. The 45Ca is taken up by a pool thought to be a component of the endoplasmic reticulum. Inositol trisphosphate induced a rapid release of Ca from this pool, suggesting that this molecule which is formed in these cells in response to f-Met-Leu-Phe may play a role in agonist-induced Ca metabolism.

Source: FEBS Letters

DOI: 10.1016/0014-5793(84)80939-4

Authors: Gillian M. Burgess, Jerry S. McKinney, Robin F. Irvine, Michael J. Berridge, Peter C. Hoyle, James W. Putney

Institutions: Virginia Commonwealth University Medical Center, University of Cambridge

Language: English

Topic: Calcium signaling and nucleotide metabolism

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2038949756

FWCI: 5.264

Cites: 15

Cited by: 61

Related to: 10