Work

Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agents

Year: 2015

Type: article

Abstract: Three series of novel compounds derived from 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid bearing piperazine carboxamides, (5-(substituted phenyl)-1,3,4-oxadiazol-2-yl) and (5-(alkylthio)-1,3,4-oxadiazol-2-yl) substitutions at the 4-position were synthesized. Synthesized compounds were characterized by 1H NMR, 13C NMR and mass spectral analysis and evaluated for their antimicrobial activities. Interestingly, most of the compounds exhibit moderate to good activities against tested Gram-positive, Gram-negative bacterial strains as well as fungal strains.

Source: Journal of Saudi Chemical Society

DOI: 10.1016/j.jscs.2015.03.003

Authors: Rahul P. Jadhav, Hemant N. Raundal, Amar A. Patil, Vivek D. Bobade

Language: English

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,490

Funders: University of the Punjab, Council of Scientific and Industrial Research, India