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Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

Year: 1996

Type: article

Abstract: Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 (basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.93.18.9850

Authors: P M Smallwood, I Munoz-Sanjuan, P Tong, J P Macke, S H Hendry, D J Gilbert, N G Copeland, N A Jenkins, J Nathans

Institutions: Howard Hughes Medical Institute, Johns Hopkins University, Houston Methodist

Language: English

Topic: Fibroblast Growth Factor Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2039358114

FWCI: 9.601

Cites: 58

Cited by: 396

Related to: 10