Associations of Insulin‐Like Growth Factor (IGF)–I and IGF‐Binding Protein–3 with HIV Disease Progression in Women
Year: 2008
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The insulin-like growth factor (IGF) axis has been hypothesized to influence the rate of human immunodeficiency virus (HIV) disease progression. This premise is based largely on laboratory models showing that IGF-I stimulates thymic growth and increases lymphocyte numbers and that IGF-binding protein (IGFBP)-3 has an opposing effect, inhibiting hematopoietic stem cell development. METHODS: We studied 1422 HIV-infected women enrolled in a large cohort that entailed semiannual follow-up (initiated in 1994). Baseline serum samples were tested for IGF-I and IGFBP-3 to determine their associations with incident clinical acquired immunodeficiency syndrome (AIDS) and CD4+ T cell count decline prior to April 1996 (before the era of highly active antiretroviral therapy [HAART]). RESULTS: Low IGF-I levels (Ptrend= .02) and high IGFBP-3 levels (Ptrend= .02) were associated with rapid CD4+ T cell count decline. Only IGFBP-3, however, was significantly associated with AIDS incidence (hazard ratio for highest vs. lowest quartile, 2.65 [95% confidence interval, 1.30-5.42]; Ptrend= .02) in multivariable models. CONCLUSIONS: These findings suggest that serum levels of IGFBP-3 (and possibly IGF-I) are associated with the rate of HIV disease progression in women and, more broadly, that interindividual heterogeneity in the IGF axis may influence HIV pathogenesis. If correct, the IGF axis could be a target for interventions to slow HIV disease progression and extend the time before use of HAART becomes necessary.
Institutions: Albert Einstein College of Medicine, University of Southern California, University of California, San Francisco, Maimonides Medical Center, Johns Hopkins University, Georgetown University, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rush University Medical Center, John H. Stroger, Jr. Hospital of Cook County, Rush University, Yeshiva University, Yale University
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Funders: National Institutes of Health, Center for AIDS Research, University of Washington, National Institute on Drug Abuse, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1025189317, HCV and HIV Progression in Women on HAART, G1072061850, G1089263533, G1252706584, G1290148215, G1383752764, G1423343497, G1440661678, G1653728403, G1919789535, G2037985070, G234908501, G2462901743, G2567544100, G2574405597, G2889922178, G3079921036, G3222910550, G3414024915, G3481933404, G3575724264, G3658850503, G3901006228, G398667773, Center for AIDS Research (CFAR), G4097647764, G4210511483, G4350804880, G4419450409, G4538066223, G4547062945, G4622231416, G4627133822, G4664570284, G4804712267, G4867537966, G4897434353, G498379488, G499585988, Chicago WIHS Consortium V (CWC), G508464731, G5282551706, G5514441876, G592158972, G621190145, G6295786800, G669420692, G6948323813, G699655281, G7017167161, HIV AND HCV DISEASE PROGRESSION IN WOMEN ON HAART, G7195401492, G769023845, G773494495, G784506540, G8121648955, G826976987, G8355300055, G893076474, G8962527242, G9000034972, G9000073987, G9000121821, G9000207004, G9000225220, G9000237332, G9000285476, G9000338758, G920507375, G925273713, G986692823
OpenAlex ID: W2039388094