Work

Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical

Year: 2012

Type: article

Abstract: A new biradical polarizing agent, bTbtk-py, for dynamic nuclear polarization (DNP) experiments in aqueous media is reported. The synthesis is discussed in light of the requirements of the optimum, theoretical, biradical system. To date, the DNP NMR signal enhancement resulting from bTbtk-py is the largest of any biradical in the ideal glycerol/water solvent matrix, ε = 230. EPR and X-ray crystallography are used to characterize the molecule and suggest approaches for further optimizing the biradical distance and relative orientation.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja212054e

Authors: Matthew K. Kiesewetter, Björn Corzilius, Albert A. Smith, Robert G. Griffin, Timothy M. Swager

Institution: Massachusetts Institute of Technology

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering