Antibodies Are Detected Against Mismatched HLA Class II Alleles and Not Class I Following Allogeneic Hematopoietic Cell Transplantation
Year: 2009
Type: article
Study design: Observational Study
Abstract: This pilot study sought to determine whether alloantibody to HLA is made in patients with acute GVHD. Day 100 serum samples of 40 recipient-donor pairs of (theoretically) single antigen/allele HLA-mismatched (MM) unrelated donor transplants performed between July 1990 and June 1999 were obtained in collaboration with the CIBMTR and NMDP. All recipients had developed acute GVHD. We measured HLA class I and II antibody (Ab) levels to the MM alleles in both the graft-versus-host (GVH) and host-versus-graft (HVG) directions.
Institutions: Stanford University, National Marrow Donor Program
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2039569603