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Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: a study of the eastern cooperative oncology group

Year: 1998
Type: article
Abstract: Squamous carcinoma of the thoracic esophagus has an extremely poor prognosis. This study, EST-1282, was undertaken by the Eastern Cooperative Oncology Group (ECOG) to determine whether the combined use of 5-fluorouracil (5-FU), mitomycin C, and radiation therapy improved the disease-free survival and overall survival of patients with carcinoma of the esophagus, compared to those who received radiation therapy alone. Two- and 5-year survivals were 12% and 7% in the radiation alone arm and 27% and 9% in the chemoradiation arm. Patients treated with chemoradiation had a longer median survival (14.8 months), compared to patients receiving radiation therapy alone (9.2 months). This difference was statistically significant. The same pattern of survival was noted in almost all subgroups independent of whether surgical resection was performed.
DOI: 10.1016/s0360-3016(98)00232-6
Authors: Thomas J Smith, Louise M Ryan, Harold O Douglass, Daniel G Haller, Yogeshwar Dayal, John Kirkwood, Douglas C Tormey, Alan J Schutt, Josephine Hinson, Benjamin Sischy
Institutions: Morristown Medical Center, Dana-Farber Cancer Institute, Roswell Park Comprehensive Cancer Center, Hospital of the University of Pennsylvania, University of Pittsburgh, University of Wisconsin–Madison, University of Wisconsin Carbone Cancer Center, Mayo Clinic, University of Rochester Medicine, University of Rochester
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,130
OpenAlex ID: W2039612753
FWCI: 10.73
Cites: 28
Cited by: 255
Related to: 10