Work

A new synthesis of the glyoxalase-I inhibitor COTC

Year: 2000

Type: article

Abstract: A stereoselective, chiral synthesis of the glyoxalase I inhibitor 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone 1 (COTC) from a simple derivative of (−)-quinic acid is described.

Source: Tetrahedron Letters

DOI: 10.1016/s0040-4039(00)00103-9

Authors: C.Frederick M Huntley, Harold B Wood, Bruce Ganem

Institution: Cornell University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,610

Funders: National Science Foundation, Waseda University, National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry

Awards: G4150770204, SYNTHESIS AND BIOSYNTHESIS IN THE SHIKIMATE PATHWAY, Purchase of a High-Field Multinuclear Nuclear Magnetic Resonance Spectrometer, Ft-Nmr Instrumentation For Research

OpenAlex ID: W2039634904

FWCI: 0.869

Cites: 16

Cited by: 33

Related to: 10