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Low Cefepime Concentrations during High Blood and Dialysate Flow Continuous Venovenous Hemodialysis

Year: 2012

Type: article

Abstract: Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.05987-11

Authors: F. Perry Wilson, Marcus A. Bachhuber, Daniel Caroff, Rebecca Adler, Douglas Fish, Jeffrey Berns

Institutions: University of Pennsylvania Health System, University of Colorado Anschutz, University of Colorado Denver

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: NxStage, National Institute of Diabetes and Digestive and Kidney Diseases