Year: 2015
Type: article
Study design: Observational Study
Abstract: The Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM-5), recommends the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 for routine clinical use. We tested the utility of the 12-item WHODAS 2.0 in prodromal Huntington disease. Using data from 726 participants and 630 companions over a 3-year follow-up, linear mixed models were fitted to test (1) baseline and longitudinal differences by progression group; (2) participant and companion differences within each group; and (3) sensitivity of the 12-item WHODAS in comparison to the 36-item WHODAS and the Total Functional Capacity (TFC) score from the Unified Huntington's Disease Rating Scale. Participants showed baseline group differences whereas companions showed baseline and longitudinal group differences. Companions reported worse functional decline over time than participants as the disease progresses. The 12-item WHODAS detected longitudinal change better than the 36-item WHODAS and the TFC in the medium progression group. Results suggest the 12-item WHODAS 2.0 can detect baseline and longitudinal differences in prodromal HD and may be useful in HD clinical trials.
DOI: 10.1038/ejhg.2015.11
Authors: the PREDICT-HD Investigators and Coordinators of the Huntington Study Group, Ji-In Kim, Jeffrey D Long, James A Mills, Nancy Downing, Janet K Williams, Jane S Paulsen
Institutions: University of Iowa, University of Iowa Health Care
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,790
Awards: Neurobiological Predictors of Huntington's Disease, 4D Shape Analysis for Modeling Spatiotemporal Change Trajectories in Huntington's, G4076936696, Basal Ganglia Shape Analysis and Circuitry in Huntington's Disease, Cognitive and functional brain changes in preclinical Huntington's disease (HD), University of Iowa Clinical and Translational Science Program, Functional Connectivity in Premanifest Huntington's Disease
OpenAlex ID: W2039932053