Work

Isolation of nuclear pore complexes in association with a lamina.

Year: 1975

Type: article

Abstract: Nuclear pore complexes have been isolated in association with a 150 A thick lamina by detergent and salt fractionation of nuclear envelopes from rat liver. The pore complexes exhibit characteristic morphology and appear to be attached in a highly specific orientation to the lamina, which extends over relatively large areas. The pore complex-lamina fraction is composed of three major and several minor polypeptides with little or no DNA, RNA, or phospholipid. It is suggested that the association of the pore complexes and the lamina reflects the structural arrangement of the nuclear periphery in vivo.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.72.3.1007

Authors: R P Aaronson, G Blobel

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2040118862

FWCI: 7.986

Cites: 43

Cited by: 377

Related to: 9