Year: 2011
Type: article
Abstract: Due to their sensitivity and temporal response, optical microresonators are used extensively in the biosensor arena, particularly in the development of label-free diagnostics and measurement of protein kinetics. In the present letter, we investigate using microcavities to probe molecules within biomimetic membranes. Specifically, a method for self-assembling lipid bilayers on spherical microresonators is developed and the bilayer-nature is verified. Subsequently, the microcavity is used to excite a Cy5-conjugated lipid located within the bilayer while the optical performance of the microcavity is characterized. The emission wavelength of the dye and the optical behavior of the microcavity agree with theoretical predictions.
Source: Applied Physics Letters
DOI: 10.1063/1.3576908
Institution: University of Southern California
Language: English
Topic: Photonic and Optical Devices
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Awards: Single Molecule Detection of Binding Kinetics, G6841935727, Nanoparticle properties and alveolar epithelial barrier/transport functions, G8555665635, Biomimetic Systems for Studying Nanoscale Structure Formation in Cell Membranes, G8876996369, Microlaser Biosensor with Integrated Dual Beam Optical Trap, G9000189479
OpenAlex ID: W2040143367