Work

Challenges in the Interpretation of Dengue Vaccine Trial Results

Year: 2013

Type: article

Abstract: Several hypotheses have been proposed to explain the unexpected results of the first completed efficacy clinical trial of a vaccine against dengue virus [1]. Based on intention-to-treat analyses, the vaccine was efficacious in reducing the incidence of clinical disease caused by dengue serotypes 1, 3, and 4, but failed to reduce the incidence of dengue-2 (DENV-2). The authors of the study propose potential explanations including an antigenic mismatch between the parental strain of the DENV-2 component and currently circulating DENV-2 viruses in Ratchaburi, an increased role for immunity to nonstructural proteins in DENV-2 that this vaccine does not induce, and a lack of correlation of measured neutralizing antibody and protective immunity [1].

Source: PLoS neglected tropical diseases

DOI: 10.1371/journal.pntd.0002126

Authors: Isabel Rodriguez-Barraquer, Luis Mier-y-Teran-Romero, Donald S. Burke, Derek A. T. Cummings

Institutions: Johns Hopkins University, United States Naval Research Laboratory, Naval Research Laboratory Plasma Physics Division, University of Pittsburgh

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,670