Work

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

Year: 1997

Type: article

Abstract: The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.

Source: Hepatology

DOI: 10.1002/hep.510260641

Authors: P J Meier, U Eckhardt, A Schroeder, B Hagenbuch, B Stieger

Institution: University Hospital Zurich

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funder: National Science Foundation

OpenAlex ID: W2040411965

FWCI: 15.79

Cites: 141

Cited by: 362

Related to: 10