Work

Effects of Dopamine on Sensitivity to Social Bias in Parkinson's Disease

Year: 2012

Type: article

Abstract: Patients with Parkinson's disease (PD) sometimes develop impulsive compulsive behaviours (ICBs) due to their dopaminergic medication. We compared 26 impulsive and 27 non-impulsive patients with PD, both on and off medication, on a task that examined emotion bias in decision making. No group differences were detected, but patients on medication were less biased by emotions than patients off medication and the strongest effects were seen in patients with ICBs. PD patients with ICBs on medication also showed more learning from negative feedback and less from positive feedback, whereas off medication they showed the opposite effect.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0032889

Authors: Atbin Djamshidian, Sean S. O'Sullivan, Andrew Lees, Bruno B. Averbeck

Institutions: University College London, National Institutes of Health, National Institute of Mental Health, UCL Queen Square Institute of Neurology

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382