Work

Population Structure of Aggarwals of North India as Revealed by Molecular Markers

Year: 2010

Type: article

Abstract: Using molecular genetic data on Aggarwals (Vaish/Vysya), an endogamous population group of north India, we provide evidence of its homogeneous unstratified population structure. We found the mean average heterozygosity value of 0.33 for 14 single nucleotide polymorphisms belonging to four genes (TCF7L2-, HHEX-, KCNJ11-, and ADIPOQ-) in the Aggarwal population (sample of 184 individuals) and tried to evaluate the genomic efficiency of endogamy in this population with the help of clan-based stratified analysis. We concluded that the sociocultural identity of the endogamous population groups could act as a robust proxy maker for inferring their homogeneity and population structure in India, which is ideal also for population selection for future genome-wide association studies in the country.

Source: Genetic Testing and Molecular Biomarkers

DOI: 10.1089/gtmb.2010.0095

Authors: Vipin Gupta, Rajesh Khadgawat, Hon Keung Tony Ng, Satish Kumar, Vadlamudi Raghavendra Rao, Mohinder Pal Sachdeva