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The Potential of Mesenchymal Stromal Cells as a Novel Cellular Therapy for Multiple Sclerosis

Year: 2012
Type: review
Abstract: Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the CNS for which only partially effective therapies exist. Intense research defining the underlying immune pathophysiology is advancing both the understanding of MS as well as revealing potential targets for disease intervention. Mesenchymal stromal cell (MSC) therapy has the potential to modulate aberrant immune responses causing demyelination and axonal injury associated with MS, as well as to repair and restore damaged CNS tissue and cells. This article reviews the pathophysiology underlying MS, as well as providing a cutting-edge perspective into the field of MSC therapy based upon the experience of authors intrinsically involved in MS and MSC basic and translational science research.
DOI: 10.2217/imt.12.41
Authors: Jeffery J Auletta, Amelia M Bartholomew, Richard T Maziarz, Robert J Deans, Robert H Miller, Hillard M Lazarus, Jeffrey A Cohen
Institutions: Rainbow Babies & Children's Hospital, Case Western Reserve University, University of Illinois Chicago, Oregon Health & Science University, Athersys (United States), Cleveland Clinic
Language: English
Field: Medicine
Open Access status: green
Awards: G1681478106, G4076603698, Immunobiology of mesenchymal stem cell transplantation in multiple sclerosis, Distinct functional phases in innate reconstitution, Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts, G8482207925
OpenAlex ID: W2041184288
FWCI: 1.403
Cites: 176
Cited by: 56
Related to: 10