Work

Six-Helix Bundles Designed from DNA

Year: 2005

Type: article

Abstract: We present a designed cyclic DNA motif that consists of six DNA double helices that are connected to each other at two crossover sites. DNA double helices with 10.5 nucleotide pairs per turn facilitate the programming of DNA double crossover molecules to form hexagonally symmetric arrangements when the crossover points are separated by seven or fourteen nucleotide pairs. We demonstrate by atomic force microscopy well-formed arrays of hexagonal six-helix bundle motifs both in 1D and in 2D.

Source: Nano Letters

DOI: 10.1021/nl050084f

Authors: Frederick Mathieu, Shiping Liao, Jens Kopatsch, Tong Wang, Chengde Mao, Nadrian C. Seeman

Institutions: Purdue University West Lafayette, New York University

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: Physical Chemistry of Recombinational intermediates, G5356741539, Physical Chemistry of Recombinational Intermediates