Work

Leukocyte Trafficking Mediated by Selectin-Carbohydrate Interactions

Year: 1995

Type: review

Abstract: The selectins have attracted intense interest because of their carbohydrate-recognition properties and their pivotal roles in leukocyte trafficking. Future studies will center on the mechanisms for regulating the expression of the selectins and their ligands, the molecular details of selectin binding to glycoprotein ligands and small carbohydrates, and the biophysical principles that selectins employ to mediate attachment and rolling of leukocytes under flow.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.270.19.11025

Authors: Rodger P. McEver, Kevin L. Moore, Richard D. Cummings

Institutions: Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funder: National Heart, Lung, and Blood Institute