Carbon Dioxide as the C1 Source for Direct C−H Functionalization of Aromatic Heterocycles
Year: 2010
Type: article
Abstract: A simple and straightforward method has been developed for the direct carboxylation of aromatic heterocycles such as oxazoles, thiazoles, and oxadiazoles using CO(2) as the C1 source. The reactions require no metal catalyst and only Cs(2)CO(3) as the base. A good functional group tolerance is achieved.
Source: Organic Letters
DOI: 10.1021/ol101450u
Authors: Oleg Vechorkin, Nathalie Hirt, Xile Hu
Institution: École Polytechnique Fédérale de Lausanne
Language: English
Subfield: Process Chemistry and Technology
Field: Chemical Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2041340439