Work

The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death

Year: 2001

Type: article

Abstract: Bloom syndrome (BS) is an autosomal recessive disorder characterized by a high incidence of cancer and genomic instability.BLM, the protein defective in BS, is a RECQ-like helicase that is presumed to function in mammalian DNA replication, recombination or repair.Because of its importance in maintaining genomic stability, we asked whether BLM was among the proteins targeted for selective degradation during the execution phase of apoptosis as has been shown recently for PARP and ATM (1, 2), among others.We show here that BLM is rapidly cleaved in cells undergoing apoptosis.

Source: The Scientific World JOURNAL

DOI: 10.1100/tsw.2001.157

Authors: Oliver Bischof, Sanjeev Galande, Terumi Kohwi-Shigematsu, Judith Campisi, Anne Dejean

Institutions: Institut Pasteur, Lawrence Berkeley National Laboratory

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $860