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Letter to the Editor: Androgens and Prostate Cancer: Are the Descriptors Valid?

Year: 2005

Type: letter

Abstract: The term androgen-independent cancer has now become a misnomer. Given that the androgen receptor can be activated by even low androgen concentrations or via protein modifications or other protein-protein interactions, a growing prostate cancer has the chance of assuming an androgen depletion-independent state, without necessarily bypassing the androgen signaling processes. It is thus suggested that "androgen-independent (AI)" cancer should be more accurately termed "androgen depletion-independent (ADI)" cancer.

Source: Cancer Biology & Therapy

DOI: 10.4161/cbt.4.1.1563

Authors: Pradip Roy-Burman, Donald J. Tindall, Diane M. Robins, Norman M. Greenberg, Mary J.C. Hendrix, Suresh Mohla, Robert H. Getzenberg, John T. Isaacs, Kenneth J. Pienta

Institutions: University of Southern California, Mayo Clinic, University of Michigan, Fred Hutch Cancer Center, Northwestern University, National Institutes of Health, National Cancer Institute, University of Pittsburgh, UPMC Hillman Cancer Center, Johns Hopkins University, U-M Rogel Cancer Center

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2041409545

Cites:

Cited by: 46

Related to: 10