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729. Phase I Trial of Intraperitoneal (IP) Administration of a Measles Virus (MV) Strain Expressing the Human Carcinoembryonic Antigen (CEA) in Ovarian Cancer Patients

Year: 2006
Type: article
Abstract: Background: Edmonston vaccine strains of MV have significant antitumor activity against ovarian cancer xenografts (Peng et al, Cancer Res, 2002). Oncolytic selectivity is due to overexpression of the MV CD46 receptor in ovarian cancer cells. Furthermore, engineering the virus to express the marker peptide CEA (MV- CEA) allows real time monitoring of viral gene expression/ propagation in vivo.
DOI: 10.1016/j.ymthe.2006.08.809
Authors: Evanthia Galanis, Lynn C. Hartmann, William A. Cliby, Paula Zollman, Prema P. Peethambaram, Harry J. Long, Judith S. Kaur, Jeff A. Sloan, Gregory A. Poland, Kah-Whye Peng, Stephen J. Russell
Institution: Mayo Clinic
Language: English
Subfield: Genetics
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2041456776
FWCI:
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