Work

Impact of Donor Stem Cell Mobilization Reactions on Reduced Intensity Haploidentical HCT Outcomes in Miniature Swine

Year: 2011

Type: article

Abstract: Toxicities and complications associated with hematopoietic cell transplantation (HCT) currently limit this potentially curative therapy for malignant and non-malignant blood disorders in the clinic. Similar to outcomes in patients, miniature swine develop severe GVHD, infectious complications or hematopioetic failure following standard clinical myeloablative conditioning and HCT. Miniature swine recipients pre-treated with a low-dose (100cGy) of total body irradiation (TBI), partial T-cell depletion using a CD3-immunotoxin prior to HCT and a 45 day course of Cyclosporine A (referred to as ITC non myeloablative conditioning) following high-dose haploidentical-HCT (5-15X109 PBMCs/kg) exhibit stable engraftment and multilineage chimerism.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2010.12.487