Unrecognized glucose intolerance is not associated with depression. Screening for Impaired Glucose Tolerance study 3 (SIGT 3)
Year: 2008
Type: article
Study design: Observational Study
Abstract: AIMS: To understand the metabolic and temporal links in the relationship between diabetes and depression, we determined the association between depressive symptoms and unrecognized glucose intolerance. METHODS: In a cross-sectional study, 1047 subjects without known diabetes were screened for diabetes or pre-diabetes using the oral glucose tolerance test and for depressive symptoms using the Patient Health Questionnaire (PHQ). RESULTS: Mean age was 48 years, body mass index 30 kg/m(2); 63% were female, 54% black, 11% previously treated for depression and 10% currently treated; 5% had diabetes and 34% pre-diabetes. Median PHQ score was 2 (interquartile range 0-5). Depressive symptoms did not increase with worsening glucose tolerance, after adjusting for age, sex, ethnicity, body mass index, family history, exercise, education and depression treatment. CONCLUSIONS: There is no association between depressive symptoms and unrecognized glucose intolerance. However, it remains possible that diagnosed diabetes, with its attendant health concerns, management issues, and/or biological changes, may be a risk for subsequent development of depression. Thus, patients with newly diagnosed diabetes should be counselled appropriately and monitored for the development of depression.
Source: Diabetic Medicine
Institution: Emory University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: American Diabetes Association, Dana Foundation, Deutsches Krebsforschungszentrum, National Institutes of Health, Agency for Healthcare Research and Quality, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1090428068, G1143685601, Mechanisms Linking Depression to Cardiovascular Risk, G1796552026, G2775279643, G2917670157, G304006002, Emory Mentored Clinical Research Scholar Program, Posttraumatic Stress Disorder and Cardiovascular Disease, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, Mind-Body Interactions in Cardiovascular Disease, GENERAL CLINICAL RESEARCH CENTER, Screening for IGT: Glucose Challenge vs Predictive Model, CVD Risk and Prevention in Early Glucose Intolerance
OpenAlex ID: W2041523272