Susceptibility variants for obesity and colorectal cancer risk: The multiethnic cohort and PAGE studies
Year: 2012
Type: article
Study design: Observational Study
Abstract: Obesity is a leading contributor to colorectal cancer risk. We investigated whether the risk variants identified in genome-wide association studies of body mass index (BMI) and waist size are associated with colorectal cancer risk, independently of the effect of obesity phenotype due to a shared etiology. Twenty-four single nucleotide polymorphisms (SNPs) in 15 loci (BDNF, FAIM2, FTO, GNPDA2, KCTD15, LYPLAL1, MC4R, MSRA, MTCH2, NEGR1, NRXN3, SEC16B, SH2B1, TFAP2B and TMEM18) were genotyped in a case-control study of 2,033 colorectal cancer cases and 9,640 controls nested within the multiethnic cohort study, as part of the population architecture using genomics and epidemiology consortium. Risk alleles for two obesity SNPs were associated with colorectal cancer risk--KCTD15 rs29941 [odds ratio (OR) for C allele = 0.90, 95% confidence interval (CI) 0.83-0.98; p = 0.01] and MC4R rs17782313 (OR for C allele = 1.12, 95% CI 1.02-1.22; p = 0.02). These associations were independent of the effect of BMI. However, none of the results remained significant after adjustment for multiple comparisons. No heterogeneity was observed across race/ethnic groups. Our findings suggest that the obesity risk variants are not likely to affect the risk of colorectal cancer substantially.
Source: International Journal of Cancer
DOI: 10.1002/ijc.27592
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Awards: Epidemiology of putative genuine genetic variant: The Women's Health Intiative, Epidemiology of Putative Causal Variants in the Multiethnic Cohort, Multiethnic Cohort Study of Diet and Cancer, NHGRI EpiGenVar Coordinating Center, Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3, G6918065631, Genetic Epidemiology of Causal Variants Across the Life Course, Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study, A Genome-wide Association Study of Prostate Cancer in African Americans, Epidemiologic Architecture for Genes Linked to Environment (EAGLE), University of Hawaii Cancer Center CCSG
OpenAlex ID: W2041579882