Work

Stepwise Development of a Homozygous S80P Substitution in Fks1p, Conferring Echinocandin Resistance in Candida tropicalis

Year: 2012

Type: article

Abstract: Three Candida tropicalis isolates were obtained from a patient with acute lymphoblastic leukemia. The first isolate was susceptible to all drug classes, while isolates 2 and 3, obtained after 8 and 8.5 weeks of caspofungin treatment, respectively, were resistant to the three echinocandins. Multilocus sequence genotyping suggested a clonal relation among all isolates. FKS1 sequencing revealed a stepwise development of a heterozygous and finally a homozygous mutation, leading to S80S/P and S80P amino acid substitutions.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01193-12

Authors: Rasmus Hare Jensen, Helle Krogh Johansen, Maiken Cavling Arendrup

Institutions: Statens Serum Institut, Copenhagen University Hospital, Rigshospitalet

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Gilead Sciences, Astellas Pharma