Year: 2013
Type: article
Abstract: Similarly to metazoans, yeast cells can exhibit several characteris-tics of apoptosis, including chromatin condensation, DNA break-age,flipping of phosphatidylserine to the outer leaflet of the plasma membrane, accumulation of reactive oxygen species (ROS), and release of pro-death factors such as cytochrome c or Endonucle-ase G from mitochondria. Yeast programed cell death has been shown to occur in response to a variety of stimuli, such as oxida-tive stress, exposure to acetic acid, and expression of mammalian pro-apoptotic proteins. This program is also inherent to the yeast life cycle, as aged mother cells and cells exposed to pheromone also display an apoptotic and necrotic phenotype. Yeast therefore com-prises a conserved core programed cell death process that shares several regulators with mammalian cells, which play major roles in the pathogenesis of human diseases. At the same time, it lacks many of the cell death regulators that have evolved in higher eukaryotes,
Source: Frontiers in Oncology
Authors: Manuela Côrte-Real, Frank Madeo
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W2041718192