Work

Gene profiling: implications in dermatology

Year: 2007

Type: article

Abstract: DNA microarrays are capable of following the level of expression of, virtually, all genes in a human tissue. This has been employed to determine the aberrant gene expression profiles in many skin diseases, including ultraviolet light damage, inflammatory processes and cancers. Because of its accessibility, skin also served as one of the initial targets of basic research using DNA microarrays. Both the epidermis and dermis have been extensively investigated. Development of bed-side uses of DNA arrays, and the concomitant price reduction of the materials and methods of microarray analyses, holds great promise for improved diagnosis, treatment and prevention of dermatologic disorders.

Source: Expert Review of Dermatology

DOI: 10.1586/17469872.2.6.763

Authors: Miroslav Blumenberg, Marjana Tomic-Canic

Institutions: New York University, Hospital for Special Surgery, Cornell University, Weill Cornell Medicine

Language: English

Topic: Gene expression and cancer classification

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Nursing Research