Work

RNAi Therapies: Drugging the Undruggable

Year: 2014

Type: article

Abstract: RNA interference (RNAi) therapy is a rapidly emerging platform for personalized cancer treatment. Recent advances in small interfering RNA delivery and target selection provide unprecedented opportunities for clinical translation. Here, we discuss these advances and present strategies for making RNAi-based therapy a viable part of cancer management.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.3008362

Authors: Sherry Y. Wu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Center for Advancing Translational Sciences