Work

The role of SMARCB1/INI1 in the development of rhabdoid tumors

Year: 2009

Type: article

Abstract: Rhabdoid tumors are especially lethal cancers that predominantly strike young children. The vast majority of rhabdoid tumors contain bi-allelic inactivating mutations in the SMARCB1 gene. Here we review clinicopathologic features of rhabdoid tumors and present recent insights into the mechanisms that drive oncogenesis in the absence of SMARCB1 function.

Source: Cancer Biology & Therapy

DOI: 10.4161/cbt.8.5.8019

Authors: Charles Roberts, Jaclyn Biegel

Institutions: Boston Children's Hospital, Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Barr Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, National Cancer Institute