Work

Evidence of synergy with combined BRAF-targeted therapy and immune checkpoint blockade for metastatic melanoma

Year: 2014

Type: article

Abstract: Significant advances in the treatment of melanoma have been made with BRAF-targeted therapy and immune checkpoint blockade, and these strategies are now being combined empirically in clinical trials. Potential synergy is demonstrated in murine models and in analysis of longitudinal biopsies from patients on trial, however important questions remain regarding toxicity, optimal timing and sequence of therapy.

Source: OncoImmunology

DOI: 10.4161/21624011.2014.954956

Authors: Zachary A Cooper, Alexandre Reuben, Rodabe N Amaria, Jennifer A Wargo

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913