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Nine-Gene Molecular Signature Is Not Associated with Prostate Cancer Death in a Watchful Waiting Cohort

Year: 2008
Type: article
Study design: Observational Study
Abstract: Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.
DOI: 10.1158/1055-9965.epi-07-0722
Authors: Lorelei A. Mucci, Yudi Pawitan, Francesca Demichelis, Katja Fall, Jennifer R. Stark, Hans-Olov Adami, Swen-Olof Andersson, Ove Andrén, Anna S. Eisenstein, Lars Holmberg, Wei Huang, Philip W. Kantoff, Sven Perner, Meir J. Stampfer, Jan-Erik Johansson, Mark A. Rubin
Institutions: Brigham and Women's Hospital, Harvard University, Karolinska Institutet, Örebro University Hospital, Uppsala University, Dana-Farber Cancer Institute, Universität Ulm, Cornell University, Weill Cornell Medicine, Weill Cornell Medical Center
Language: English
Field: Medicine
Open Access status: bronze
Awards: Prostate Cancer Harbinger Genes, G2477279009, G3393943949, G3549828030, G4069844214, G5078901805, G8478755887, G9000017514, G9000025535, G9000036166, Program for Training in Cancer Epidemiology
OpenAlex ID: W2042320528
FWCI: 1.39
Cites: 17
Cited by: 12
Related to: 10