Year: 1991
Type: article
Abstract: THE segregation of membrane proteins into specialized domains is important for many aspects of cell function, especially those involving cell-cell interaction and conununication. Of particular interest to cellular and molecular neurobiologists are the highly specialized distributions of ion channels at synapses. Both the pre- and postsynaptic membranes exhibit organized arrays ofion channels that are important for synaptic transmission. At the neuromuscular junction, voltage-activated calcium channels are clustered at presynaptic active zones (62), the sites of acetylcholine release. Directly across the synaptic gap from active zones are regions of the postsynaptic membrane containing extraordinarily high concentrations (8-10,000/pz) of nicotinic acetylcholine receptors (AChR) ' (24). A few microns away from the synapse, the concentration of receptors
Source: The Journal of Cell Biology
DOI: 10.1083/jcb.114.1.1
Author: S C Froehner
Institution: Dartmouth College
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2042450135